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Guidance to the heart

Guidance to the heart

CUPIDO aims to improve the specificity to the heart by using a chemical-based targeting system. To achieve this aim, on the surface of the nanoparticles have been included aptamers that should enhance the internalization into myocardial cells. Aptamers, which are short single-stranded oligonucleotides of modified DNA or RNA, are emerging as very interesting molecules that can fold into complex tertiary structures and bind with high affinity to a cell-selective target. If the target is undergoing receptor-mediated cell internalization, it can serve as a carrier for intracellular delivery too. In CUPIDO the CNR-IRGB identified promising aptamers that target the myocardium and promote the internalization while the CNR-ISTEC functionalized and characterized the nanoparticles with the selected aptamers. Once the nanoparticle-aptamer systems were ready, the CNR-IRGB tested their behavior in vitro and confirmed…
The nanoparticle biodistribution

The nanoparticle biodistribution

During the last year, BET Solutions has managed to radiolabel the nanoparticles in order to follow their distribution in the body after administration. So far, the intravenous administration route was used as a reference since it represents the most commonly-used path to deliver pharmaceuticals into the body. The in vivo fate of the NPs was assessed through planar Single Photon Emission Tomography (SPECT) imaging, in combination with x-ray imaging. While the SPECT imaging provides a semi-quantitative picture of the accumulation of the nanoparticles in the organs throughout time, the x-ray imaging instead provides an anatomical image at very high resolution, that can act as an anatomical map. The combination of the two methods provides a detailed and clear biodistribution of the tracked nanoparticles up to 24 hours. In the future,…
In vitro biocompatibility with the lung

In vitro biocompatibility with the lung

The Lung Cell Biology group at the Imperial College London is performing a preliminary in vitro assessment of the nanoparticles behavior with the lungs cells, the first target that the nanoparticles encounter before translocating to the heart. In order to study the biocompatibility, a broad range of concentrations of nanoparticles have been applied to alveolar type 1 cells and analyzed after 24 hours, looking in particular for cell survival rates and a sign of inflammation. Overall, these preliminary studies indicate that the nanoparticles did not induce cell death when applied to the alveolar epithelial type 1-like model. Further studies are required to quantify particle uptake and to complete the bioreactivity studies in more physiological-like conditions that take into account the air exposure and blood flow dynamics. For this reason, the…
News on “Circulation”

News on “Circulation”

CUPIDO has been featured in the cardiology news section of the journal Circulation "From the Literature". The article "Inhalation Therapy May Help Treat Heart Failure" highlights the recent discoveries published in Science Translational Medicine journal. You can read the full article here.
CUPIDO workshop

CUPIDO workshop

During the last project meeting, held in Sanofi offices near Paris, CUPIDO hosted a workshop focused on the present state of the regulations in nanomedicine. Among the speakers, Patrick Boisseau by ETP Nanomedicine gave a clear overview of the European ecosystem in nanomedicine (here the presentation) and Simon Baconnier from EU-NCL provided useful tips on the European infrastructure to improve translation in nanomedicine (here the presentation).  Thanks to all the participants to make the workshop successful, it was a great chance to network with other interesting initiatives in nanomedicine in Europe.
CUPIDO News Digest

CUPIDO News Digest

Here a selection of some interesting recent scientific papers related to CUPIDO's research. BIOMATERIALS TO FIGHT CARDIOVASCULAR DISEASES: FROM BENCH TO BEDSIDE  This review of Materials Today highlights how nanomedicines (i.e. nanoparticles and drugs) offer interesting perspectives in the treatment of atherosclerosis and heart ischemia, potentially affording new tools in the fight against cardiovascular diseases. The authors, however, notice a gap between the preclinical findings and their validation in clinical trials, due to difficulties in translating the tests in animal models to patients. They suggest several solutions to bridge the gap of nanomedicine from bench to bedside: The modes of administrations tested in preclinical models such as the direct myocardium injection should be better evaluated with human physiology in mind; The physicochemical characteristics of nanomedicines and its potential toxicity should be…
Publication on Science Translational Medicine

Publication on Science Translational Medicine

A new study, carried out by the group of Daniele Catalucci from the CNR-IRGB (Milan, Italy), one of the key partners of the EU-funded project CUPIDO, demonstrated that nanoparticle-encapsulated pharmacologically active peptides can be efficiently delivered to the heart via inhalation. These results, published in the journal “Science Translational Medicine”, represent the first proof-of-concept for an unconventional and pioneering approach exploiting inhalable nanoparticle properties to improve diseased cardiac conditions. As Michele Miragoli, first author of the paper explains: “Nanomedicine, meaning the application of nanotechnology to the health sector, represents a promising approach for near future health care. Indeed, several nanopharmaceuticals have been approved by the FDA since the late 90s’  leading to remarkable advantages especially in the cancer field. Curiously, only very few attempts have been made to apply nanomedicine…
1st paper for CUPIDO!

1st paper for CUPIDO!

One of the CUPIDO partner's, Michele Miragoli, part of the CNR-IRGB team, has published the first publication about the research done within CUPIDO! The paper "Cardiac kinematic parameters computed from video of in situ beating heart" has been published in the journal Scientific Reports and presents a new imaging modality, which extracts useful parameters from videos of a beating heart, displaying live cardiograms of the contraction events. The paper, published as open access, is available at the Publication section.
The meeting season has started

The meeting season has started

The project has started and partners are working together to build a fruitful collaboration! This month several meetings have taken place to pull together partners located all around Europe. Plumestars (Parma, Italy), for example, has hosted partners from IRGB-CNR (Milan, Italy) and Nemera (La Verpillière, France) (see the picture), and a meeting with CNR-ISTEC (Faenza, Italy).