CUPIDO News Digest

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Here a selection of some interesting recent scientific papers related to CUPIDO’s research.

BIOMATERIALS TO FIGHT CARDIOVASCULAR DISEASES: FROM BENCH TO BEDSIDE

 This review of Materials Today highlights how nanomedicines (i.e. nanoparticles and drugs) offer interesting perspectives in the treatment of atherosclerosis and heart ischemia, potentially affording new tools in the fight against cardiovascular diseases. The authors, however, notice a gap between the preclinical findings and their validation in clinical trials, due to difficulties in translating the tests in animal models to patients. They suggest several solutions to bridge the gap of nanomedicine from bench to bedside:

  1. The modes of administrations tested in preclinical models such as the direct myocardium injection should be better evaluated with human physiology in mind;
  2. The physicochemical characteristics of nanomedicines and its potential toxicity should be finely controlled to allow for reproducibility of obtained therapeutic results;
  3. Elementary nanocarriers, pharmaceutically easier to develop and whose preparation is transportable to the industrial scale should replace the complex architectural design of many nanomedicines.

At CUPIDO, we specifically address the first solution by developing a non-invasive drug-delivery system for CVD based on inhalable nanoparticles that should deliver a therapeutic directly to the diseased hearth.

Flavio Dormont, et al. “Nanoplumbers: biomaterials to fight cardiovascular diseases”  Materials Today, August 2017 – LINK

NANOPARTICLES FOR CARDIAC REPAIR

In a recently published article, a team of researchers from the University of Helsinki explored the potential of employing porous silicon nanoparticles to deliver medicines to the injured heart tissue through intravenous administration. The nanoparticles’ surface has been engineered to ensure the targeting to the heart, thanks to specific molecular recognition. In their study, the researchers elucidate the material toxicity and interaction mechanism of the nanoparticles with cardiac cells. Moreover, the nanoparticles loaded with a novel cardioprotective small molecule showed a promising cardioprotective effect by modulating cellular processes involved in heart hypertrophy. These results provide a valuable insight into the development of nano-therapies targeted to the myocardium, which is also one of the objectives of CUPIDO.

Mónica P. A. Ferreira, et al. “Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling” Small 2017, 13, https://doi.org/10.1002/smll.201701276

MANNITOL AS AN IDEAL EXCIPIENT FOR SPRAY-DRIED NANO-EMBEDDED MICROPARTICLES DIRECTED TO THE LUNGS

Nano-embedded microparticles represent a promising approach to deliver nanoparticles to the lungs and, with an appropriate aerodynamic diameter, they enable an application with dry powder inhaler. By disintegration after deposition, nanoparticles can be released to exhibit their advantages such as a sustained drug release and delivery of the drug across the mucus barrier. The use of an appropriate excipient to embed the nanoparticles is essential for the necessary disintegration and release of nanoparticles. In this context researchers from the Saarland University investigated the influence of the excipient mannitol on the behavior of nano-embedded microparticles. By enabling the release of nanoparticles from nano-embedded microparticles, mannitol was shown to be an ideal excipient to convert nanoparticles by spray drying into an inhalable dry powder formulation. CUPIDO aims to develop an inhalable dry powder formulation having as final target the heart while the lungs represent a mere intermediate step.

Afra Torge et al. “The influence of mannitol on morphology and disintegration of spray-dried nano-embedded microparticles” https://doi.org/10.1016/j.ejps.2017.04.003