Inhalable nanoparticles to the heart
Inhalable nanoparticles to the heart
Nanotechnology meets cardiology
Nanotechnology meets cardiology
A therapy as simple as breathing
A therapy as simple as breathing
Background
Our Goal
Consortium

THE BREATHING HEART

1. Nanoparticle production
Biocompatible and biodegradable nanoparticles can self-assemble and encapsulate drugs
2. Inhalation
Nanoparticles are transformed into an inhalable coarser dry powder that can reach the airways.
3. Crossing the pulmonary barrier
Nanoparticles can cross the alveolar-capillary barrier, rapidly reaching the heart
4. One target: the heart
The heart specificity is ensured thanks to chemical and magnetic guidance

THE CONSORTIUM

99
Research groups
99
SMEs
99
Pharma Company
99
Industries

NEWS

Guidance to the heart
Guidance to the heart
June 5, 2018
CUPIDO aims to improve the specificity to the heart by using a chemical-based targeting system. To achieve this aim, on the surface of the nanoparticles have been included aptamers that should enhance the internalization into myocardial cells.
The nanoparticle biodistribution
The nanoparticle biodistribution
June 5, 2018
During the last year, BET Solutions has managed to radiolabel the nanoparticles in order to follow their distribution in the body after administration. The combination of two methods provides a detailed and clear biodistribution of the tracked nanoparticles up to 24 hours.
In vitro biocompatibility with the lung
In vitro biocompatibility with the lung
June 4, 2018
The Lung Cell Biology group at the Imperial College London is performing a preliminary in vitro assessment of the nanoparticles behavior with the lungs cells, the first target that the nanoparticles encounter before translocating to the heart.